Endocrine Abstracts

There is evidence from animal studies that 1,25-dihyroxyvitamin D3 (1,25(OH)2D3) is essential for normal reproductive function. Vitamin deficient rats have reduced fertility and VDR null mutant mice demonstrate impaired folliculogenesis. One small uncontrolled study in humans has demonstrated that vitamin D replacement improves menstrual frequency and acne in women with polycystic ovary syndrome (PCOS). We have previously demonstrated that 1,25(OH)2D3 inh...